Tuesday, December 2, 2008

Urinary Bisphenol A, medical disorders, and laboratory abnormalities

Scott shared an article published in JAMA re: the association between urinary BPA concentrations and health status. BPA is a widely used epoxy resin that lines food and beverage containers.

Citation: Lang, I.A., Galloway, T.S., Scarlett, A. et al., (2008). Association of Urinary Bisphenol concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300, 1303-1310.

This is a cross-sectional analysis of 1455 adults (18-74 years) in the general population who participated in the National Health and Nutrition Examination Survey (2003-4)

Key independent variable: urinary BPA concentrations

Dependent variables: chronic disease diagnoses; liver function; glucose homeostasis, inflammation, lipids

Analysis: regression models controlling for age, sex, race/ethnicity, education, income, smoking, body mass index, waist circumference, and urinary creatinine concentration.

Main findings: Higher urinary BPA was associated with cardiovascular diagnoses (OR per 1 SD increase in BPA = 1.39, p<.001) and diabetes (OR = 1.39, p<.001), but no other studied diseases. It was also associated with elevated liver enzymes.

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